How should we use ALK inhibitors separately?

Predicted values: how should we use them?

ERK pathway inhibitors: how low should we go?

Resistance to RAF inhibitors is generally accompanied by reactivation of extracellular signal-regulated kinase (ERK) signaling. SCH772984, a selective, ATP-competitive inhibitor of ERK1 and ERK2, is effective in BRAF-mutant models in which resistance is the result of ERK reactivation. SCH772984 may also have a role in the treatment of tumors in which ERK is dysregulated by mutant RAS, NF1, or a...

Tranexamic acid in trauma: how should we use it?

Tranexamic acid (TXA) reduces blood loss by inhibiting the enzymatic breakdown of fibrin. It is often used in surgery to decrease bleeding and the need for blood transfusion. In 2011, results from a multi-center, randomized, and placebo-controlled trial (CRASH-2 trial) showed that TXA (1 g loading dose over 10 min followed by an infusion of 1 g over 8 h) safely reduces mortality in bleeding tra...

How Should We Teach Simulation ?

This paper deals with the issue of how one can teach simulation in the most time-efficient way. We first distinguish between different types of student as regards their background and future needs. We next look at reasons for studying simulation at a business school. Next we compare animation oriented simulators with simulation languages. We then study a list of desirable criteria for simulatio...

How should we define health?

Machteld Huber senior researcher, J André Knottnerus president, Scientific Council for Government Policy , Lawrence Green editor in chief, Oxford Bibliographies Online—public health , Henriëtte van der Horst head , Alejandro R Jadad professor , Daan Kromhout vice president, Health Council of the Netherlands , Brian Leonard professor , Kate Lorig professor , Maria Isabel Loureiro coordinator for...